Chronic venous insufficiency (CVI) of the legs is one of the most common diseases (prevalence 3-5 percent) in adults in the western population with considerable socio-economic importance. The insufficiency of the venous valves disrupts the return of blood to the heart and leads to a local excess pressure in the venous system of the legs. This leads to dilated veins, varicose veins, heavy and painful legs with swelling, skin and tissue changes and in the final stage to chronic leg ulcers (leg ulcers). The current therapies are mainly symptomatic (elevation of the legs, lymph drainage, compression therapy), or treat the complications (treatment of chronic wounds, removal of varicose veins) but not the cause. Previous approaches to the reconstruction of venous valve function (surgical, interventional) have not been successful due to the special coagulation situation in the venous flow region.
Total budget: 2,258,111.83 €.
Grant: € 1,832,273.50