BioTex - Publikation Anja Lüngen

17/06/2022

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Anja Lüngen

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Luengen AE, Cheremkhina M, Gonzalez-Rubio J, Weckauf J, Kniebs C, Uebner H, Buhl EM, Taube C, Cornelissen CG, Schmitz-Rode T, Jockenhoevel S and Thiebes AL (2022) Bone Marrow Derived Mesenchymal Stromal Cells Promote Vascularization and Ciliation in Airway Mucosa Tri-Culture Models in Vitro. Front. Bioeng. Biotechnol. 10:872275. doi: 10.3389/fbioe.2022.872275

https://www.frontiersin.org/article/10.3389/fbioe.2022.872275

The publication “Bone Marrow Derived Mesenchymal Stromal Cells Promote Vascularization and Ciliation in Airway Mucosa Tri-Culture Models in Vitro” from Anja E. Luengen et al. was published in Frontiers in Bioengineering and Biotechnology. In this publication, vessel formation mediated by endothelial cells is combined with mucociliary differentiation of respiratory epithelial cells through fibrin-based tri-culture with supporting cells such as mesenchymal stem cells of different origin and fibroblasts. Currently, there is no viable treatment option for severe airway stenosis by tracheal replacement. Tissue engineering may in the future provide feasible solutions to overcome current limitations with regard to epithelialization, blood supply and mechanical stability. Pre-vascularization can ensure sufficient nutrition of a tissue-engineered construct while in vitro differentiation of the respiratory epithelium provides a functional mucociliary clearance at the time of implantation. In addition, regenerative effects of mesenchymal stem cells may assist in establishing and maintaining the functionality of a tissue-engineered graft. Our vascularized and mucociliated mucosa model contributes to the development of a complete tracheal replacement and can additionally be further evolved as disease model for the respiratory tract.