Here you will find our projects sorted by topicality:
Resorbable medical solutions from the Aachen technology region - reACT. Within the framework of a RUBIN-alliance, implant concepts are developed in this joint project, which are intended to meet the urgent clinical need for temporally adaptive partially resorbable endoluminal support structures (stents).
Das TeXlastins project aims to translate the design principles found in nature to the laboratory, with the target mission of developing functional cardiovascular implants.
New Ways to accelerate Translation - Bridging academic and industrial research for optimal translation into clinic. NeWTranslation
BioBased Value Circle
The BioBased Value Cirle aims to contribute to the development of a circular biobased economy by exploiting the potential of biobased materials.
The Breathing Gut
Enteral CO2 elimination in the treatment of chronic hypercapnic respiratory failure. The beathing Gut
Efficient cell coating of biohybrid lungs by atomization of shear-stress resistant endothelial cells derived from induced pluripotent stem cells. EndoSpray
Influence of a biohybrid lung on inflammatory pathways and immune system endothelial cell interaction. EndOxy in Flame
The Optimize project aims to develop an innovative implant for the treatment of hyperplastic left heart syndrome.
BioV2alve deals with the development of biohybrid venous valves for minimal invasive treatment of chronic veneous insufficiency.
The aim of the Implant Monitoring project is to establish longitudinal monitoring of tissue maturation and to validate it in animal experiments. To this end, an understanding of the biological dynamics of the insertion and remodelling process of biohybrid cardiovascular implants will be gained using the example of the geometrically simple vascular prosthesis. In order to investigate the interactions between (i) biomaterial, (ii) cellular components and (iii) implant environment non-invasively, methods of hybrid MR-PET and molecular ultrasound imaging will be investigated and tested.
As part of the MEꓱT graduate program "Mechanobiology in Epithelial 3D Tissue Constructs", we are investigating in our subproject C3 "Guiding respiratory epithelium towards directed ciliary function" which biomechanical stimulation is necessary for in vitro conditioning of respiratory epithelium to achieve functional mucociliary clearance.
The aim of the project Fontan is to improve the quality of life and prevent morbidity and mortality in patients in the Fontan circulation. This is to be achieved by generating an autologous, flap-bearing, contractile conduit in the sense of a subpulmonary neo-ventricle.
The project pHMed researchs solution spun PLA fibres with pH-neutral degradation characteristics.
To improve life quality of lung cancer patients we develop the PulmoStent, a biohybrid respiratory stent.
In the CellSpray project, we are working on the application of an innovatice spraying process for local cell therapy of the lungs.
In the EndOxy project we are developing a biohybrid lung that enables patients with life-threatening lung failure to receive long-term lung support.
The BioPacer project is developing a biological pacemaker for babies and children.Traditional pacemakers are too big for the chest.The "BioPacer" consists of a small cylinder that is populated with endogenous cells of the heart-sick child and cultivated in a bioreactor. It will treat heart rhythm disorders.
We are developing a fully functional windpipe with capillary-like structures in the TracheaPrint project.
The E-Suture project is investigating the use of tension-optimising materials and yarn structures as surgical suture material.
Development of biofunctional hybrid membranes for permanent implant materials FilaMem.