AMB - Advanced Materials for Biomedicine
Laura De Laporte
Abteilungsleiterin Advanced Materials for Biomedicine
- 0241 80 23309
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At AMB, we synthesize and apply polymeric molecular and nano- to micron-scale building blocks to assemble soft 3D biomaterials with anisotropic and dynamic properties. Microgels and fibers are produced by technologies based on fiber spinning, microfluidics, and in-mold polymerization. To arrange the building blocks in a spatially controlled manner, self-assembly mechanisms and assembly by external magnetic fields are employed. For example, the Anisogel technology offers a solution to regenerate sensitive tissues with an oriented architecture, which requires a low invasive therapy. It can be injected as a liquid and structured in situ in a controlled manner with defined biochemical, mechanical, and structural parameters. Magnetoceptive, anisometric microgels or short fibers are incorporated to create a unidirectional structure. Cells and nerves grow in a linear manner and the fibronectin produced by fibroblasts is aligned. Regenerated nerves are functional with spontaneous activity and electrical signals propagating along the anisotropy axis of the material. Another developed platform is a cell-adhesive thermoresponsive hydrogel system, encapsulated with plasmonic gold-nanorods, which actuates by oscillating light under physiological conditions. This system elucidates how rapid hydrogel beating leads to a reduction in cell migration, while enhancing focal adhesions, native production of extracellular matrix, and nuclear translocation of mechanosensitive proteins, depending on the amplitude and frequency of actuation.