CVE - Projects

 

Here you will find all current projects.
You will find our finished projects in the navigation bar on the left.

Our projects are supported by the German Research Foundation (DFG), the Federal Ministry of Education and Research (BMBF), the European Union and the Land Nordrhein-Westfalen, as well as the INTERREG Programme V-A Euregio Maas-Rhein of the European Union and the Medical Faculty of the RWTH Aachen University (IZKF and START).

 

3DLung

The core technology of so-called artificial lungs are membranes that allow diffusive gas exchange between blood and gas phase similar to the native human lung. In the research project “3D-Lung”, we evaluate the next generation of oxygenator membranes based on 3D-printing technology with the potential for an implantable artificial lung by overcoming the current limitations of stand-of-the-art membranes.
Funded by the DFG. This project is part of the SPP 2014: Towards an Implantable Lung.
Aim of the SPP is to enable research to support the development of long-term implantable lung assist systems.

 

DurImplant

The aim of project “DurImplant” is the development of an in vitro methodology for the investigation of the durability of biohybrid implants with main focus on the propensity to calcification as a decisive limiting factor of the implant lifetime and function.
Funded by the DFG. This project is part a Sub-project P5 of PAK 961 DFG project "Towards a model based control of biohybrid implant maturation" .

 

Fluorescent Ghosts

The minimization of hemolysis is a core objective of the development of blood-bearing medical devices such as blood pumps or heart valves.
The PIV measurement allows for a spatially resolved flow analysis and can reveal possible sources of hemolysis. In standard-compliant in-vitro experiments, blood is used as the test medium. Here, however, only the blood damage of the entire system can be quantified. These two aspects can be combined with the help of so-called ghost cells.
Within the scope of the Ghostcell follow-up project, the Fluorescent Hemolysis Detection with PIV will be combined, optimized and validated in-vitro to finally enable the spatially resolved hemolysis detection in blood-bearing medical devices.

 

HBOX

Development of a new therapy system for the treatment of CO poisoning.

 

HemoSim

Better understanding of mechanically induced hemolysis using experimental and numerical methods to improve the design of current blood-carrying medical devices
Funded by the DFG.

 

Interventional measurement

For over 20 years catheter based implantations of artificial heart valves provide an alternative to open heart surgery. The success of a catheter-based implantation depends, inter alia, on the knowledge of the measurement and form of the pathological heart valve. The implantation of an inaccurately sized heart valve can lead to severe complications. As conventional imaging-techniques show divergent measurements, a concept for a new measurement device is developed in this project.
Funded by the START-Program of the Faculty of Medicine, RWTH Aachen.

 

Valve thrombogenicity

Risk assessment of the thrombogenicity of biological prostheses in vitro.The aim of this project is the qualitative assessment of the risk for valve thrombosis in biological prostheses within an in vitro study. In addition, risk factors for thrombus formation are derived from the site of origin, size and number of thrombi.
Funded by the Hirsch Stiftung.

 

Surface Structures

Improving the hemocompatibility of polyurethane by means of surface structuring.
Funded by the START-Program of the Faculty of Medicine, RWTH Aachen.

 

OxySim 2

Aim of the OxySim 2 project is to establish a method for a quantitative prediction of gas transfer in oxygenators.
Funded by the DFG.

 

Oxytestfluid

In the project Oxytestfluid, investigations on blood substitutes are performed and a novel test method for reproducible, preclinical performance testing of artificial lungs is developed.
Funded by the START-Program of the Faculty of Medicine, RWTH Aachen.

  Logo of the project

Perinatal Life Support System

The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of extremely preterm born infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo.
Funded by Horizon 2020.

 

ReinHeart

Aim of the project ReinHeart is the development of a fully implantable total artificial heart that functions without any connection through the skin.
Funded by the European Union and Land Nordrhein-Westfalen .

 

RenOX

Development of a medical device for combined pulmonary and renal support therapy.
Funded by the DFG. This project is part of the SPP 2014: Towards the implantable lung.
The goal of the SPP is to support research leading to the development of a long-term implantable lung support system.

 

Thrombosurf

Thrombogenicity Reduction by Means of Surface Structures – A Combined In-silico and In-vitro Study.
Funded by the DFG and the ANR (France).

 

Thrombosis test system: Investigation of polymeric valves in aortic position

In-vitro test system to check the thrombogenicity of Prosthetic Heart Valves

 

TIBET

in-vitro approach to assess the thrombotic potential in blood-recirculating devices to facilitate research and development, regulatory processes, and to better understand the process of thrombosis.

 

VA-ECMO Sim

Flow study in femoro-femoral VA ECMO and the analysis of afterload elevation and Harlequin syndrome using virtual models.

 

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