CVE - Research Areas
Therapies and Applications
- Developing and Testing novel valve repair and replacement devices and other minimally invasive interventional medical products.
Heart valve regulatory testing according to DIN EN ISO 5840 can be performed in-house due to the close collaboration with our spin-off company ac.biomed and newly developed methods can be applied industry-related.
- Development and testing of lung assist systems both for use as a heart-lung machine and for ECLA application.
Primary goals are the miniaturization of the systems for small patients for example neonates and adaptation to the patients´ individual needs.
By close cooperation with our fully equipped blood laboratory, all in accordance to DIN EN ISO 7199 necessary oxygenator tests can be carried out in house.
- Researching, developing and testing innovative blood pump concepts. The current developments of the workgroup focus on miniaturized heart support pumps for minimally invasive implantation and on heart replacement with a fully implantable total artificial heart.
Some of the concepts were successfully translated to clinical applications.
Research and Validation
- The Field consists of members from a range of disciplines for example engineers, scientists, technical stuff which generates a specialized multidisciplinary approach to biomedical engineering.
- The research is focused on the experimental investigation of interactions between biological and technical systems in the field of cardiovascular engineering. A special emphasis lays on the understanding of blood damage for example thrombogenesis, hemolysis due to technical systems as well as the development of experimental test methods on the basis of DIN ISO 10993-4.
The results are implemented in new development approaches and are used to improve existing applications. Thus, they contribute to the development of future cardiovascular devices.
- Experimental simulation is used as a tool to support the development and optimization of blood pumps, heart valve prostheses and artificial lungs.
The tasks are divided into the fields of Mock Circulatory Loops MC, for example the CVE-Loop, flow visualization using Particle Image Velocimetry, in short: PIV, calcification tests, durability testing, kinematic and hydrodynamic studies and thrombogenicity testing.
The main focus is the development of new experimental methods.
Modeling and Simulation
- We employ numerical simulation as a tool to support the development and optimization of blood pumps, heart valve prostheses and artificial lungs. The tasks are divided into flow simulation, mass transfer simulation and structural analysis for the modeling of the interactions between biological and technical systems in the cardiovascular field of application. The development of numerical evaluation and experimental validation methods are an important focus.