Oxytestfluid - Blood replacement fluid for performance testing of artificial lungs

Contact

Name

Johanna Clauser

Chief Scientist Research & Validation

Phone

work
+49 241 80 89356

Email

E-Mail
 

Background

Chronic lung diseases and their consequences are the fourth leading cause of death worldwide. A shortage of donor organs and long waiting times for lung transplantation lead to the treatment with technical alternatives as of extracorporeal membrane oxygenation (ECMO). Artificial lungs are used for this type of long-term application, but also in short-term applications such as cardiopulmonary bypasses. A fundamental part of the development process of artificial lungs are tests to verify the performance of the devices. Currently, this requires substantial in-vivo studies in animal models or in vitro with whole blood.

Objective

In order to establish a safe and fast validation of new types of artificial lungs or ones under research, a blood substitute is to be developed in an interdisciplinary cooperation. The blood substitute shall imitate the properties of whole blood with respect to the rheology and gas transport behaviour. With this fluid it will be possible to significantly shorten the development process of artificial lungs, so that technological progress will find its way into medical applications more quickly and at lower cost.

Methods

Different perfluorocarbon based emulsions are prepared and investigated with respect to stability, polydispersity, rheology and oxygen transport capacity.

Funding This research project is supported by the START-Program of the Faculty of Medicine, RWTH Aachen
Cooperation Partner Research Area Functional and Interactive Polymers and DWI - Leibniz Institute for Interactive Materials