When testing blood conducting systems regarding blood damage, flow measurements and in-vitro-blood-tests play a central role. However, a series of optical measuring methods cannot be performed with blood due to the lack of transparency. This issue is resoved by using Ghost Cells.
Funded by the DFG.
Atrial fibrillation leads to a five-fold increase in the stroke risk. If treatment of the atrial fibrillation fails and long-term anti-coagulation carries to much risk in a patient, the stroke risks can be reduced by implanting an occluder in the left atrial appendage (LAA). In the PLAAO project, we design a personalized LAA occluder that will improve the closure of the LAA and reduce the risk to the patient.
Funded by the BMBF.
OxySim (finished 08/2019)
Computational Fluid Dynamics, CFD, supports the development process of oxygenators significantly. Aim of the project OxySim is to develop the numerical model further, as well as to validate it in vitro.
HOC Surf (finished 07/2019)
People who live with an implanted ventricular assist device have to fuly rely on this. The fact that todays ventricular assist devices come with a life-threatening risk of thrombosis is even more severe for those being affected. Therefore, CVE and its cooperation partners investigate in the project HOC Surf intensively the applicability of innovative coating processes. It is our goal to enable patients to live their lifes without any risk of thrombosis through a gentle contact between blood and device.
ProtEmbo (finished 10/2018)
The acute aortic valve stenosis is one of the most commonly observed heart valve diseases. Affected patients with a high operation risk are treated with transcatheter aortic valve implantation (TAVI), a minimally invasive procedure. This procedure comes with several risks. The development of a novel embolic protection device, the ProtEmbo device, is expected to minimize neurological complications during TAVI.
Scarabeusheart (finished 03/2018)
The Scarabaeus heart project is researching a new generation of blood pumps. For this purpose, the rotary piston principle is used, which has become known to the public through the Wankel engine. The approach combines the advantages of different blood pumps and is intended to avoid medical complications caused by previously used designs. Different applications are possible, e.g. as a fully implantable cardiac support system or as a complete heart replacement.
EndOxy (finished 12/2017)
Chronic airway disease is the third most frequent cause of mortality. However, the therapy of chronic lung disease is limited to a duration of weeks due to insufficient biocompatibility of extracorporeal membrane oxygenation (ECMO) devices. The underlying idea in the research project “EndOxy” is to overcome this limitation by benefitting from the physiological antithrombotic properties of an endothelial lining similar to the native blood vessels. A biohybrid solution with endothelial layer covering the blood contacting surfaces as a biomimicking interface between technical promises an increase of hemocompatibility and, thus, allows prolonged ECMO therapy for patients with chronic lung disease.
Isolated Heart (finished 06/2016)
The Isolated Heart is a standardized test procedure for percutaneous aortic valve prostheses.
Potential of von Willebrand Factor for early detection and differentiation of shear related blood damage by blood pumps