CVE - Projects


Here you will find all current projects in alphabetical order.
You will find a breakdown of the individual funding organisations in the navigation bar on the left.



This project is part of the SPP 2014: Towards an Implantable Lung.

The core technology of so-called artificial lungs are membranes that allow diffusive gas exchange between blood and gas phase similar to the native human lung. In the research project “3D-Lung”, we evaluate the next generation of oxygenator membranes based on 3D-printing technology with the potential for an implantable artificial lung by overcoming the current limitations of stand-of-the-art membranes.



This project is part of the SPP 2014: Towards an Implantable Lung .

Lung support systems replace the lung function of patients with critical lung disease. Especially for these highly fragile patients the procedure poses a considerable risk. The aim of the project “ConnexAL” is the development and evaluation of a less invasive technique, which reduces the risk and increases the mobility for the patient. An early mobilization after surgery supports the healing process and improves the quality of life.



This project is part of the SPP 2014: Towards an Implantable Lung .

The cannulation of Extracorporeal Lung Assist (ECLA) systems is still a source of undesired complications . The project “ConnLA” aims for an alternative to conventionally used cannula such as hemodynamically optimized grafts directly connected to blood vessels.



This project is part a Sub-project P5 of PAK 961 DFG project "Towards a model based control of biohybrid implant maturation"

The aim of project “DurImplant” is the development of an in vitro methodology for the investigation of the durability of biohybrid implants with main focus on the propensity to calcification as a decisive limiting factor of the implant lifetime and function.



To close this temporal gap between the diagnosis of a carbon monoxide intoxication and the HBO therapy, the project ECCOR will develope a system for the elimination of carbon monoxide.



Chronic airway disease is the third most frequent cause of mortality. However, the therapy of chronic lung disease is limited to a duration of weeks due to insufficient biocompatibility of extracorporeal membrane oxygenation (ECMO) devices. The underlying idea in the research project “EndOxy” is to overcome this limitation by benefitting from the physiological antithrombotic properties of an endothelial lining similar to the native blood vessels. A biohybrid solution with endothelial layer covering the blood contacting surfaces as a biomimicking interface between technical promises an increase of hemocompatibility and, thus, allows prolonged ECMO therapy for patients with chronic lung disease.


Fontan Pro

Failing-Fontan is a present problem, which confronts cardiologists in the whole world. The Fontan-procedure enables children to survive with only one functioning ventricle. The treatment of this innate heart defect is individual for each patient and requires in some cases a cardiac support system.


Ghost Cells

When testing blood conducting systems regarding blood damage, flow measurement and blood tests play a central role. However, a series of optical measuring methods can not be performed with blood due to the lack of transparency. This issue is resoved by using Ghost Cells.


HOC Surf

People who live with an implanted ventricular assist device have to fuly rely on this. The fact that todays ventricular assist devices come with a life-threatening risk of thrombosis is even more severe for those being affected. Therefore, CVE and its cooperation partners investigate in the project HOC Surf intensively the applicability of innovative coating processes. It is our goal to enable patients to live their lifes without any risk of thrombosis through a gentle contact between blood and device.


Interventional measurement

For over 20 years catheter based implantations of artificial heart valves provide an alternative to open heart surgery. The success of a catheter-based implantation depends, inter alia, on the knowledge of the measurement and form of the pathological heart valve. The implantation of an inaccurately sized heart valve can lead to severe complications. As conventional imaging-techniques show divergent measurements, a concept for a new measurement device is developed in this project.


Surface Structures

Improving the hemocompatibility of polyurethane by means of surface structuring.



“OxyBench” is an interdisciplinary research project aiming for a simulation and test platform for novel membrane oxygenators and technologies in artificial lungs for the treatment of chronic lung disease. The test methods within this project are developed to allow reproducible, preclinical long-term tests of artificial lungs.



Computational Fluid Dynamics, CFD, supports the development process of oxygenators significantly. Aim of the project OxySim is to develop the numerical model further, as well as to validate it in vitro.



Atrial fibrillation leads to a five-fold increase in the stroke risk. If treatment of the atrial fibrillation fails and long-term anti-coagulation carries to much risk in a patient, the stroke risks can be reduced by implanting an occluder in the left atrial appendage (LAA). In the PLAAO project, we design a personalized LAA occluder that will improve the closure of the LAA and reduce the risk to the patient.



Prosthetic heart valves are the sole effective treatment in patients with valvular heart disease. The project Polyvalve develops a Polymeric Prosthetic Heart Valve for Life.



The acute aortic valve stenosis is one of the most commonly observed heart valve diseases. Affected patients with a high operation risk are treated with transcatheter aortic valve implantation (TAVI), a minimally invasive procedure. This procedure comes with several risks. The development of a novel embolic protection device, the ProtEmbo device, is expected to minimize neurological complications during TAVI.



The PulmoStent is a multi-layer biohybrid Stent for the treatment of airway stenoses.



Aim of the project ReinHeart is the development of a fully implantable total artificial heart that functions without any connection through the skin



Aim of the project ReinHeart is the development of a fully implantable total artificial heart that functions without any connection through the skin


Thrombosis test system: Investigation of polymeric valves in aortic position

In-vitro test system to check the thrombogenicity of Prosthetic Heart Valves