Funded by Faculty of medicine RWTH (IZKF and START)
Interdisciplinary Centre for Clinical Research
Chronic airway disease is the third most frequent cause of mortality. However, the therapy of chronic lung disease is limited to a duration of weeks due to insufficient biocompatibility of extracorporeal membrane oxygenation (ECMO) devices. The underlying idea in the research project “EndOxy” is to overcome this limitation by benefitting from the physiological antithrombotic properties of an endothelial lining similar to the native blood vessels. A biohybrid solution with endothelial layer covering the blood contacting surfaces as a biomimicking interface between technical promises an increase of hemocompatibility and, thus, allows prolonged ECMO therapy for patients with chronic lung disease.
For over 20 years catheter based implantations of artificial heart valves provide an alternative to open heart surgery. The success of a catheter-based implantation depends, inter alia, on the knowledge of the measurement and form of the pathological heart valve. The implantation of an inaccurately sized heart valve can lead to severe complications. As conventional imaging-techniques show divergent measurements, a concept for a new measurement device is developed in this project.
Improving the hemocompatibility of polyurethane by means of surface structuring.
“OxyBench” is an interdisciplinary research project aiming for a simulation and test platform for novel membrane oxygenators and technologies in artificial lungs for the treatment of chronic lung disease. The test methods within this project are developed to allow reproducible, preclinical long-term tests of artificial lungs.