Modeling of delivery and release of therapeutic systems

Student looks at a coil filled with magnetic nanoparticles Copyright: Benedikt Marcowka

Magnetic nanoparticles can be used to deliver therapeutic drugs, such as chemotherapeutics, to the tumor site resulting in a reduction of side-effects and a higher dose at the tumor site. For this, drugs bound to magnetic nanoparticles are injected into a blood vessel and attracted to the tumor by using magnetic fields. The drugs can then be released directly inside the tumor, for instance by applying heat which is provided by the nanoparticles to the tumor. This is feasible because magnetic nanoparticles transform the energy of an external alternating magnetic field into heat. The heat additionally damages the tumor at a temperature of approximately 43 C, so-called hyperthermia.
In order to attract as much nanoparticles as possible at the tumor site, the group of Dr. Slabu is developing a physical model for magnetic nanoparticle targeting with specific magnet configurations, which are endoscopically placed inside the body. Physicians could then use this model for therapy planning. The researchers verify the model in computer simulations as well as in in-vitro and in-vivo experiments.

Partners:

European Surgical Center Aachen Maastricht Department of General, Visceral and Transplant Surgery University Hospital RWTH Aachen